How to detect the right information from the brain to see a seizure coming?

It looks like the best way to detect the onset of an epileptic insult is by doing a wavelet transform on the acquired ECoG. However, which morphological features to look at is far from trivial. For the first generation of closed-loop neurostimulators it is therefore probably best to acquire the complete ECoG signal at full resolution and do the morphological analysis in the digital domain entirely. In a later phase, the (analog) frontend (sense amplifier) can be made more specific, thereby releasing the burden from the analog-to-digital converter and the signal processing in the digital domain.