Do you really listen or hear?

Learning in the true sense of the word is possible only in that state of attention, in which there is no outer or inner compulsion. Right thinking can come about only when the mind is not enslaved by tradition and memory.”

–  Jiddu Krishnamurti

Considering all the senses we possess, the post could have been named “Do we see or look?” or perhaps  “Do we speak or talk?”. But among the three, I would like to focus more on the capability to hear and listen, which also holds relevance to the research conducted at the bioelectronics group. To provide a sense of appreciation, simply look at how elegantly the brain processes the sounds we hear, with clear distinctions in frequency and amplitude making innumerable nervous connections, to generate a unique experience. For instance, when you hear the far away church bell ringing in a crowded marketplace, it fills you with joy and hope. If you care about the quality of the sound and prefer using high end headphones, you would know the joy of heavy bass sound and clear vocals that you savor while listening to music!

With tremendous advancements in microelectronics, thousands of individuals with varying degrees of disabilities are now able to hear better with the support of hearing aids, where the size of the aid is diminishing rapidly, while maximizing comfort. As an example, the cochlear implants (CI) are being used for the restoration of the hearing ability and is on the road to absolute bliss in audition. As exciting and extreme the research continues to be, I would like to draw your attention to the significance of listening, going beyond hearing, and the differences lying therein.

Although we have managed to bring about considerable improvement in the hearing abilities of the people through scientific progress, have the fully abled beings actually made complete use of the capabilities in a way that would enhance their personalities and their understanding? Do we truly listen?

Difference between hearing and listening

When we hear someone speak, we produce our own formulations and thoughts, we are either accepting or rejecting his/her idea, as the speaker speaks. We stand to compare his words with what we think based on the background, knowledge base and the experience we possess. This very fact is the denial of listening. While hearing is the ability to perceive sound by detection of the changes in pressure in the surrounding medium, which is involuntary, listening is an act you choose to do voluntarily, a decision you take consciously.

In Jiddu Krishnamurti’s words, in listening there is no comparison, neither is there acceptance nor rejection. The quality of listening is your attention. When you listen, every part of your body is in rapt attention to what is being spoken, intensely, where there is no judgement. There is no confusion but absolute clarity. You are neither influenced by the person’s appearance, nor intimidated by his presence. When you do that, you listen to the subject of discussion wholly. You are then in a position to discriminate right from wrong. There is a strong inner urge to understand the speech fundamentally, and not superficially be steered by the speaker and/or being ignorant. You are then very observant of the changes that are taking place within you, subtle nevertheless. A detailed discussion is available here for the interested reader.

Krishnamurti speaks in depth about the state of the mind while listening. A calm mind can perceive and listen with great clarity. Also, such a mind can have positive influence on the environment, the essence of which is well captured in one of Krishnamurti’s commentaries about “The noisy child and the silent mind” and is available here. As another example, in the movie Karate Kid (2010), Kung Fu master Mr. Han (Jackie Chan) takes Dre Parker (Jaden Smith) to the Dragon well on top of the mountain. Mr.Han explains the state of mind of the lady (who controlled the snake) which was calm and still just like the water in the well where Dre looks at his own reflection. The scene is available here (Watch from 1:13:00 to 1:17:10).

To give an analogy in the circuits and signal processing domain, when we need to acquire a signal, while ensuring quality and reproducibility in the digital domain for a given application, both internal and external noise have to either be minimized or rejected. In the same way, only a quiet mind can perceive and experience what is beyond hearing and also understanding. And often, the quality of listening goes with the choice of words one uses in his/her speech. As you begin to listen better, your thoughts become refined and so do your words. You then begin to filter all that is noise and only recover your signal of interest.

On another note, it is important to use one’s own discretion in placing the attention. Considering the information society we live in, there is a vast wealth of information on every subject. What we choose to learn is an individual choice. A wealth of information creates a dearth of attention, derived from the concept of attention economy, first studied extensively by Herbert Simon.

While we aim to bring about improvement in the the lives of people with hearing disabilities, we also need to give a thought towards how effectively we use our perfectly functioning abilities. How we take things for granted! If we didn’t, the experience would be more enriching, so much more happier and so much more wholesome!

As Helen Keller said,
So much has been given to me I have not time to ponder over that which has been denied.
This should not only motivate oneself to look within, reflecting on the challenges and converting every disadvantage to an advantage, but also placing a check on whether we use our inherent faculties to the total extent. It is just like owning a Lamborghini Aventador but being limited to use it as a Dacia Sandero on legal roads or employing an ARM micro-controller to make an LED blink!

                                                   ***
About Jiddu Krishnamurti

jk  Born (11 May 1895 ) in Mandanpalle, Andhra Pradesh, India, Jiddu Krishnamurti, an Indian philosopher, is globally regarded as one of the greatest educators and thinkers. He had a deep sense of appreciation and respect for nature, as it appears in his notes. When he spoke, he did so with his own insight and vision, which had a certain directness and freshness.

About Hellen Keller

hk Born (27th June 1880) in Tuscumbia, Alabama, U.S., Hellen overcame the adversity of being deaf and blind to become one of the 20th century’s leading humanitarians as quoted here.

Suggested reading and references

  • Commentaries on Living, Jiddu Krishnamurti
  • Education and the significance of life, Jiddu Krishnamurti
  • Story of my life, Hellen Keller

 

calvin

 

 

Optogenetics: lighting the way to the future

Article in Maxwell, the quarterly magazine of the Electrotechnische Vereeniging, ETV, Issue 18.4, by Farnaz Nassiri Nia, MSc Student in the Section Bioelectronics on the basic principles of optogenetics and a state-of-the-art bioelectronics application for the treatment of epilepsy.

The brain is the mystery of the human body. Neurons, as primary units of the nervous system, are joined together into a complicated biological interconnected network. A conventional method to manipulate the neural performance within this network is to use drugs that alter the chemical balance of the brain. However, a crucial aspect of the nervous systems is the electrical signalling between the neurons. Bioelectronics has advanced the neural modulation techniques beyond the conventional methods by developing electrical brain stimulation tools. Electrical brain stimulation is truly beneficial to understand the mechanism underlying neural behaviour, and develop novel therapeutic methods. Optogenetics is another breakthrough method in neural stimulation techniques, which has opened up entirely new avenues of research opportunities in the fields of neuroscience and bioelectronics. In this article, the basic principles of optogenetics and a state-of-the-art bioelectronics application for the treatment of epilepsy are described.

Een betere toekomst begint vandaag

maslov_eeVoor verwelkoming van de aankomende 1e-jaars van de opleiding Electrical Engineering aan de TU Delft maakte ik tijdens het “Electro Ontvangst Weekend” (EOW) een presentatie. Deze presentatie vind je hier: http://elca.et.tudelft.nl/~wout/tmp/eow_2015_serdijn.pdf.

Neural stimulation: design of efficient and safe neural stimulators

Article by Marijn van Dongen on efficient and safe neurostimulation

Article by Marijn van Dongen, honorary aluminus of the Bioelectronics Group, in Maxwell 18.3, the quarterly magazine of the Electrotechnische Vereeniging, on the work he did for his PhD studies on power efficient and safe neurostimulation.

Read the entire article here: http://elca.et.tudelft.nl/~wout/tmp/neurostimulation_maxwell_18.3_vandongen.pdf

Lecture on Electroceuticals: getting better with electricity

Lecture on Electroceuticals: getting better with electricity

Lecture on Electroceuticals: getting better with electricity

On May 6, 2015, Collegerama of TU Delft made video recordings of the lecture I gave on Electroceuticals.

Electroceuticals are the electronic counterparts of pharmaceuticals and are miniature electronic devices that interact with the body in an electrical fashion.

In this talk I discuss: neurostimulation and the need to make neurostimulators smaller, more power efficient and more intelligent; optogenetic neuromodulation and the need to make this new neuromodulation modality operate in a closed-loop fashion; neurosensing devices to make neurostimulators intelligent and thereby adjust themselves to the therapeutical needs of the patient; autonomous wireless sensor nodes that can measure temperature or the electrocardiogram without the need for a battery; an outlook into the future of electroceuticals with the promise to treat a larger variety of neurological and brain disorders better.

Click here to start watching the video and slides:

https://collegerama.tudelft.nl/Mediasite/Play/cc7888beb88349c1a60c1414476b577a1d?catalog=528e5b24-a2fc-4def-870e-65bd84b28a8c

The injectable neurostimulator: an emerging therapeutic device

The injectable neurostimulator: an emerging therapeutic device

Xiaolong Li1Wouter A. Serdijn2Wei Zheng1Yubo Tian1Bing Zhang1
1 School of Electronics and Information, Jiangsu University of Science and Technology, Zhenjiang, China
2 Section of Bioelectronics, Delft University of Technology, Delft, the Netherlands

Available online 25 April 2015

Highlights

  • Injectable neurostimulators (InNSs) for clinical use are necessary to avoid the side effects of the dominant bulky implantable neurostimulator.
  • The concept, implementation challenges, and development trends of the InNS are illustrated in detail.
  • The new generation of InNSs can be powered from a microbattery, a radio-frequency energy harvester, or an inductive coupling link.
  • Obstacles include the implementation of injectable batteries, injectable antennas, and radio-frequency energy harvesters; the realization of InNSs also awaits breakthroughs in soft and bendable materials, reliability, and the mode of injection.

Injectable neurostimulators are currently applied in clinical trials to minimize the side effects such as discomfort, risk of infection, and post-surgery trauma, which can be pronounced with conventional, bulky implantable neurostimulators. Owing to its smaller size, wireless-updatable software, and wireless power supply, the injectable neurostimulator is presumably less invasive, ‘smarter’, and has a longer lifetime. We discuss the concept and development of the injectable neurostimulator, persistent implementation challenges, and obstacles to be overcome in its evolution. We survey the use of new materials, technologies, and design methods for injectable electrodes, batteries, antennas, and packaging to enhance reliability and other features. These advances in the field are accompanied by progress in electrophysiology, neuroscience, neurology, clinical trials, and treatments.

Keywords

  • biocompatible materials;
  • electrical nerve stimulation;
  • injectable neurostimulator;
  • injectable electronic devices;
  • therapeutic device

REMINDER: ISCAS 2015 Advance Registration Deadline (April 30th) Approaching Quickly

REMINDER: ISCAS 2015 Advance Registration Deadline Notice & Call for Participation

2015 IEEE International Symposium on Circuits and Systems (ISCAS) Lisbon, Portugal
24-27 May 2015

http://www.iscas2015.org/

ISCAS 2015 HIGHLIGHTS:
– Keynote by Behzad Razavi: “The Future of Radios”
– Keynote by Ronald Dekker: “From Chips for the Living to Living Chips”
– Keynote by Luís Gomes: “Changing the Economics of Space: Small Spacecraft and COTS Electronics”
– John Choma Commemorative Session on Reconfigurable and Adaptive Analog, Mixed-Signal, and Radio-Frequency Integrated Circuits, with contributions from Yannis Tsividis, Franco Maloberti, Edgar Sanchez-Sinencio, Hossein Hashemi and Randy Geiger.
– John Choma Commemorative Session on Ultra-Low-Power Integrated Circuits and Systems for Biomedical Implants, with contribution from Mohamad Sawan, Ralph Etienne-Cummings, Wouter Serdijn, Herming Chiueh and Roman Genov.
– Conference Leadership Workshop

HOTEL RESERVATIONS:
Rooms at different hotels in Lisbon have been booked for the convenience of the participants and are to be assigned on a first-come first-served basis. Please visit the conference web site for additional information.

http://www.iscas2015.org/travel/hotels/

Advance Registration Deadline: April 30th

GENERAL CHAIRS’ MESSAGE

Queridos amigos,

On behalf of the Organizing Committee, we are pleased and honored to invite and welcome you to Lisbon and to the 2015 IEEE International Symposium on Circuits and Systems (ISCAS 2015). The conference theme, “Enabling Technologies for Societal Challenges”, in line with the 2020 European Research and Innovation Roadmap and the Grand Engineering Challenges, suits extremely well our community’s inter-disciplinary and cross-disciplinary research activities.

ISCAS is the main event of the IEEE Circuits and Systems Society and the world’s premier networking forum for leading researchers in the highly active fields of theory, design and implementation of circuits and systems. The Technical Program Co-Chairs for this year edition, João Goes and Philipp Häfliger, have assembled an outstanding program with three full days of lectures and poster sessions covering 16 tracks. The most outstanding contributions to these tracks will be considered for the Best Student Paper Award contest and the Best Live Demo Award contest. The winners of both awards will be selected and announced during the conference.

ISCAS 2015 also offers high-quality and leading–edge tutorials and special sessions from worldwide experts, either in specific and in multidisciplinary areas, suited for those looking for a birds-eye view on a new research area or to improve their areas of expertise.

A set of world-class keynote speeches will be presented.

Apart from the scientific contributions, ISCAS 2015 will offer a forum that promotes the interaction between industry, start-ups, PhD students, academia and research funding agencies. This interaction will have place through industry presence, debates and talks.

ISCAS 2015 maintains the Women in CAS (WiCAS) activity as well as the Young Professionals Program (YPP) activity and will also host a “Conference Leadership Workshop”, a Special “John Choma Commemorative” Session with 10 distinguished invited speakers and other events, further enriching the technical program.

As for the social program we will try to match the quality of the technical program and of the tutorial offerings. On Tuesday, the Award Ceremony will be held in an opera house auditorium followed by the Gala Dinner in the Convento do Beato, a magnificent former monastery that dates back to the 15th century.

ISCAS 2015 will assist in sharing and disseminating your specific and inter- and cross-disciplinary technical achievements and will bring together diverse participants, histories and cultures. We look forward to your active participation in this magnificent event!

Um abraço,
Jorge Fernandes and Wouter Serdijn

Nieuwe stimulatie-methode effectiever tegen hersen- en zenuwaandoeningen

Persbericht van de TU Delft, uitgegeven vandaag (23 april 2015):
Nieuwe stimulatie-methode effectiever tegen hersen- en zenuwaandoeningen 

HF_stimulatorHersenstimulatie wordt tegenwoordig succesvol toegepast ter bestrijding van ziektes als Parkinson, chronische depressie, pijn en tinnitus. Door neurostimulatoren energiezuiniger en kleiner te maken, kunnen ze doelgerichter en voor een groter scala aan hersen- en zenuwaandoeningen worden ingezet. Marijn van Dongen maakte een prototype van een chip waarmee deze vorm van neurostimulatie kan worden toegepast. Hij promoveert op vrijdag 24 april op dit onderwerp aan de TU Delft. 

Parkinson

Hersenstimulatie wordt tegenwoordig succesvol toegepast ter bestrijding van ziektes zoals Parkinson, chronische depressie, pijn en tinnitus en er zijn aanwijzingen dat hersenstimulatie ook succesvol kan zijn in de behandelingen van nog veel meer hersenaandoeningen, zoals epilepsie, verslavingen, migraine en dementie. Veel bestaande neuro-stimulatoren hebben echter een beperkte energie-efficiëntie, waardoor een grote batterij nodig is. Een grote batterij maakt de hele neurostimulator groot waardoor deze niet op de plaats geïmplanteerd kan worden waar de stimulatie ook daadwerkelijk nodig is. Vaak verbinden onderhuidse draden de neurostimulator in de borst met de elektroden in de hersenen.

HF

Daarom is aan de TU Delft een nieuwe manier van neurostimulatie onderzocht: hoog-frequente (HF) neurostimulatie. De doelmatigheid van deze HF-stimulatie in aangetoond via simulaties en met in-vitro-metingen (in samenwerking met de afdeling Neurowetenschappen van het Erasmus Medisch Centrum). HF-stimulatie heeft hetzelfde effect op weefsel als klassieke stimulatie, alleen kan HF-stimulatie energiezuiniger zijn. De batterij kan daarmee kleiner worden en er zijn minder ruimte-verslindende componenten nodig.

Pulsjes

‘In mijn promotieonderzoek hebben we gefocust op nieuwe stimulatie-patronen die efficiënt opgewekt kunnen worden’, zegt Marijn van Dongen. ‘In plaats van met een constante stroom, stimuleren we de hersenen met een serie hoogfrequente stroom-pulsjes. Dit soort pulsjes kunnen op een energie-efficiënte manier worden opgewekt dankzij het principe van een geschakelde voeding. We hebben een energiezuinige neurostimulator-chip ontworpen die tot wel 200% energiezuiniger kan zijn dan zijn klassieke tegenhangers. Hierdoor kunnen toekomstige neurostimulatoren kleiner worden gemaakt en daarmee voor een groter scala aan hersen- en zenuwaandoeningen worden ingezet. Bovendien kunnen deze pulsjes verschillende doelen tegelijkertijd activeren en daarmee de doelmatigheid van de neurostimulatie verhogen.’

Prototype

Er is een prototype chip ontwikkeld waarmee deze vorm van neurostimulatie kan worden toegepast. In samenwerking met neurowetenschappers van het Erasmus Universitair Medisch Centrum, de University of Texas at Dallas (VS) en de University of Otago (Nieuw-Zeeland) is de methode succesvol geverifieerd.

Colloquium

Voorafgaand aan de promotie van Marijn van Dongen is er een colloquium over neurostimulatie door prof. Dirk De Ridder: the future of brain, spine and nerve stimulation. Prof.dr. Dirk De Ridder bekleedt de Neurological Foundation Chair in Neurosurgery aan de Dunedin School of Medicine, University of Otago, Nieuw-Zeeland (vrijdag 24 april, 10.00-11.15 uur; Snijderszaal: EWI-LB01.010, TU Delft).

Meer informatie
Voor meer informatie neemt u contact op met Marijn van Dongen, afdeling Micro-Elektronica van de faculteit Elektrotechniek, Wiskunde en Informatica, M.N.vanDongen@tudelft.nl, 06 – 435 70479 of met Claire Hallewas, wetenschapsvoorlichter TU Delft, C.R.Hallewas@tudelft.nl, 015 – 27 84259. Het volledige proefschrift vindt u op de TU Delft repository.”

Electroceuticals: the Shocking Future of Brain Zapping

Electroceuticals are the electronic counterparts of pharmaceuticals

“It’s all in your head—those icky feelings, all that fog—and chemicals just aren’t that great at cutting through. That’s why scientists are experimenting with changing the brain game by tweaking its circuitry, rather than the chemical processes.

It might be a bit unnerving to us seasoned pill-poppers, but some believe that electrical currents could be the new wave in everything cerebral, from treating depression and addiction to enhancements that would enable those seeking that mental edge to learn new skills faster or remember more.”

Read more at: http://motherboard.vice.com/read/electroceuticals-the-shocking-future-of-brain-zapping.

Future hardware improvements in implantable hearing devices

Damaged situation of the middle and inner ear; hair cells are damaged or non-existent, nerve cells are not fully developed or do not reach the cochlea [3].

Damaged situation of the middle and inner ear; hair cells are damaged or non-existent, nerve cells are not fully developed or do not reach the cochlea [3].

In this essay, by Ide Swager, MSc student in bioelectronics, an overview of current and future developments in implantable hearing devices is presented. It has been written as part of the course Introduction to Microelectronics for the M.Sc. track Microelectronics of the faculty Electrical Engineering, Mathematics and Computer Science of Delft University of Technology. A brief version of the auditory anatomy is included to clarify the causes of deafness. After elaborating on the current devices available and the basic working principle, future trends are explored. These include Neural Response Telemetry (NRT), combined Acoustic and Electric Stimulation (EAS) and binaural devices.

Read the full essay here: http://elca.et.tudelft.nl/~wout/tmp/iswager_essay.pdf